hackfile.py

import mmap
import struct

print(struct.unpack('<i', b'\xa0\xcf\x6e\x44'))   # 1148112800
struct.unpack('>i', b'\x95\x6b\x31\x93')    # -1788137069


with open('tmp', 'rb', 0) as file, \
     mmap.mmap(file.fileno(), 0, access=mmap.ACCESS_READ) as s:
     pos = s.find(b'\x64\x65')
     if pos != -1:
        x=struct.unpack('cc', s[pos+2:pos+4])
        print(x)