Created
March 20, 2020 10:14
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FE GraphQL Schema
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| directive @cacheControl(maxAge: Int, scope: CacheControlScope) on FIELD_DEFINITION | OBJECT | INTERFACE | |
| type Abstract { | |
| title: String! | |
| } | |
| type AdverseEventRow { | |
| event: String! | |
| count: Int! | |
| llr: Float! | |
| } | |
| enum AssociationType { | |
| RESISTANT | |
| RESPONSIVE | |
| NOT_RESPONSIVE | |
| INCREASED_TOXICITY | |
| } | |
| type Author { | |
| firstName: String | |
| lastName: String | |
| initials: String | |
| } | |
| enum CacheControlScope { | |
| PUBLIC | |
| PRIVATE | |
| } | |
| type CancerHallmarkPromotionAndSuppression { | |
| name: String! | |
| promotes: Boolean! | |
| suppresses: Boolean! | |
| } | |
| type CancerHallmarkPublication { | |
| pmId: String! | |
| description: String! | |
| } | |
| type CancerHallmarkPublicationFullDetails { | |
| name: String! | |
| promotes: Boolean! | |
| suppresses: Boolean! | |
| description: String! | |
| pmId: String! | |
| } | |
| type CancerHallmarkPublicationsByHallmark { | |
| name: String! | |
| promotes: Boolean! | |
| suppresses: Boolean! | |
| publications: [CancerHallmarkPublication!]! | |
| } | |
| type CancerHallmarkRoleInCancer { | |
| name: String! | |
| pmId: String! | |
| } | |
| type CategoryFacetItem { | |
| itemId: String! | |
| name: String! | |
| count: Int! | |
| } | |
| type ClinicalTrial { | |
| phase: Int! | |
| status: ClinicalTrialStatus | |
| sourceUrl: String! | |
| sourceName: String! | |
| } | |
| enum ClinicalTrialStatus { | |
| ACTIVE_NOT_RECRUITING | |
| COMPLETED | |
| NOT_APPLICABLE | |
| NOT_YET_RECRUITING | |
| RECRUITING | |
| SUSPENDED | |
| TERMINATED | |
| UNKNOWN_STATUS | |
| WITHDRAWN | |
| ENROLLING_BY_INVITATION | |
| } | |
| enum DataSource { | |
| OT_GENETICS_PORTAL | |
| PHEWAS_CATALOG | |
| EVA | |
| EVA_SOMATIC | |
| GENE2PHENOTYPE | |
| GENOMICS_ENGLAND | |
| INTOGEN | |
| CANCER_GENE_CENSUS | |
| REACTOME | |
| PROGENY | |
| SLAPENRICH | |
| CRISPR | |
| SYSBIO | |
| CHEMBL | |
| EXPRESSION_ATLAS | |
| EUROPEPMC | |
| PHENODIGM | |
| UNIPROT | |
| UNIPROT_SOMATIC | |
| UNIPROT_LITERATURE | |
| } | |
| type DataSourceFacetItem { | |
| itemId: DataSource! | |
| name: String! | |
| count: Int! | |
| } | |
| enum DataType { | |
| GENETIC_ASSOCIATION | |
| SOMATIC_MUTATION | |
| KNOWN_DRUGS | |
| PATHWAYS | |
| DIFFERENTIAL_EXPRESSION | |
| ANIMAL_MODELS | |
| TEXT_MINING | |
| } | |
| type DataTypeFacetItem { | |
| itemId: DataType! | |
| name: String! | |
| count: Int! | |
| children: [DataSourceFacetItem!] | |
| } | |
| type DifferentialExpressionActivity { | |
| url: String! | |
| name: String! | |
| } | |
| type DifferentialExpressionExperiment { | |
| url: String! | |
| name: String! | |
| } | |
| type Disease { | |
| id: String! | |
| name: String! | |
| description: String! | |
| synonyms: [String!]! | |
| therapeuticAreas: [Disease!]! | |
| summaries: DiseaseSummaries! | |
| details: DiseaseDetails! | |
| targetsConnection(facets: DiseaseTargetsConnectionFacetsInput, sortBy: DiseaseTargetsConnectionSortByInput, first: Int, after: String, search: String): DiseaseTargetsConnection! | |
| } | |
| type DiseaseDetailDrugs { | |
| rows: [EvidenceRowDrugs!]! | |
| } | |
| type DiseaseDetailOntology { | |
| nodes: [DiseaseOntologyNode!]! | |
| therapeuticAreas: [String!]! | |
| } | |
| type DiseaseDetailPhenotypes { | |
| rows: [DiseasePhenotype!]! | |
| } | |
| type DiseaseDetailRelatedDiseases { | |
| rows: [RowRelatedDisease!]! | |
| expanded(otherEfoId: String!): [ExpandedRowRelatedDisease!]! | |
| } | |
| type DiseaseDetails { | |
| drugs: DiseaseDetailDrugs | |
| ontology: DiseaseDetailOntology | |
| phenotypes: DiseaseDetailPhenotypes | |
| relatedDiseases: DiseaseDetailRelatedDiseases | |
| } | |
| type DiseaseOntology { | |
| nodes: [DiseaseOntologyNode!]! | |
| therapeuticAreas: [String!]! | |
| } | |
| type DiseaseOntologyNode { | |
| id: String! | |
| name: String! | |
| parentIds: [String!]! | |
| } | |
| type DiseasePhenotype { | |
| id: String! | |
| name: String! | |
| url: String! | |
| } | |
| type DiseaseSummaries { | |
| drugs: DiseaseSummaryDrugs | |
| ontology: DiseaseSummaryOntology | |
| phenotypes: DiseaseSummaryPhenotypes | |
| relatedDiseases: DiseaseSummaryRelatedDiseases | |
| } | |
| type DiseaseSummaryDrugs { | |
| drugCount: Int! | |
| sources: [Source!]! | |
| } | |
| type DiseaseSummaryOntology { | |
| isTherapeuticArea: Boolean! | |
| isLeaf: Boolean! | |
| sources: [Source!]! | |
| } | |
| type DiseaseSummaryPhenotypes { | |
| phenotypesCount: Int! | |
| sources: [Source!]! | |
| } | |
| type DiseaseSummaryRelatedDiseases { | |
| relatedDiseasesCount: Int! | |
| sources: [Source!]! | |
| } | |
| type DiseaseTargetsConnection { | |
| totalCount: Int! | |
| facets: DiseaseTargetsConnectionFacets! | |
| edges: [DiseaseTargetsConnectionEdge!]! | |
| pageInfo: PageInfo! | |
| } | |
| type DiseaseTargetsConnectionEdge { | |
| id: String! | |
| node: Target! | |
| score: Float! | |
| scoresByDataType: [ScoreForDataType!]! | |
| scoresByDataSource: [ScoreForDataSource!]! | |
| } | |
| type DiseaseTargetsConnectionFacetDataTypeAndSource { | |
| items: [DataTypeFacetItem!]! | |
| } | |
| input DiseaseTargetsConnectionFacetInputDataTypeAndSource { | |
| dataTypeIds: [DataType!] | |
| dataSourceIds: [DataSource!] | |
| } | |
| input DiseaseTargetsConnectionFacetInputPathways { | |
| pathwayIds: [String!] | |
| } | |
| input DiseaseTargetsConnectionFacetInputTargetClass { | |
| targetClassIds: [String!] | |
| } | |
| input DiseaseTargetsConnectionFacetInputTissueSpecificity { | |
| tissueIds: [String!] | |
| } | |
| input DiseaseTargetsConnectionFacetInputTractability { | |
| tractabilityIds: [String!] | |
| } | |
| type DiseaseTargetsConnectionFacetPathways { | |
| items: [SinglyNestedCategoryFacetItem!]! | |
| } | |
| type DiseaseTargetsConnectionFacets { | |
| dataTypeAndSource: DiseaseTargetsConnectionFacetDataTypeAndSource | |
| pathways: DiseaseTargetsConnectionFacetPathways | |
| targetClass: DiseaseTargetsConnectionFacetTargetClass | |
| tractability: DiseaseTargetsConnectionFacetTractability | |
| tissueSpecificity: DiseaseTargetsConnectionFacetTissueSpecificity | |
| } | |
| input DiseaseTargetsConnectionFacetsInput { | |
| dataTypeAndSource: DiseaseTargetsConnectionFacetInputDataTypeAndSource | |
| pathways: DiseaseTargetsConnectionFacetInputPathways | |
| targetClass: DiseaseTargetsConnectionFacetInputTargetClass | |
| tractability: DiseaseTargetsConnectionFacetInputTractability | |
| tissueSpecificity: DiseaseTargetsConnectionFacetInputTissueSpecificity | |
| } | |
| type DiseaseTargetsConnectionFacetTargetClass { | |
| items: [SinglyNestedCategoryFacetItem!]! | |
| } | |
| type DiseaseTargetsConnectionFacetTissueSpecificity { | |
| items: [TissueSpecificityFacetItem!]! | |
| } | |
| type DiseaseTargetsConnectionFacetTractability { | |
| items: [CategoryFacetItem!]! | |
| } | |
| enum DiseaseTargetsConnectionSortByField { | |
| GENETIC_ASSOCIATION | |
| SOMATIC_MUTATION | |
| KNOWN_DRUGS | |
| PATHWAYS | |
| DIFFERENTIAL_EXPRESSION | |
| ANIMAL_MODELS | |
| TEXT_MINING | |
| SCORE_OVERALL | |
| TARGET_SYMBOL | |
| } | |
| input DiseaseTargetsConnectionSortByInput { | |
| field: DiseaseTargetsConnectionSortByField! | |
| ascending: Boolean! | |
| } | |
| type Drug { | |
| id: String! | |
| name: String! | |
| synonyms: [String!]! | |
| tradeNames: [String!]! | |
| yearOfFirstApproval: String | |
| type: String! | |
| maximumClinicalTrialPhase: Int | |
| hasBeenWithdrawn: Boolean! | |
| withdrawnNotice: WithdrawnNotice | |
| summaries: DrugSummaries! | |
| details: DrugDetails! | |
| internalCompound: Boolean! | |
| } | |
| enum DrugActivity { | |
| POSITIVE_MODULATOR | |
| NEGATIVE_MODULATOR | |
| OTHER | |
| } | |
| type DrugDetailAdverseEvents { | |
| critval: Float! | |
| rows: [AdverseEventRow!]! | |
| } | |
| type DrugDetailLinkedDiseases { | |
| rows: [Indication!]! | |
| } | |
| type DrugDetailLinkedTargets { | |
| rows: [Target!]! | |
| } | |
| type DrugDetailMechanismsOfAction { | |
| rows: [MechanismOfActionRow!]! | |
| } | |
| type DrugDetails { | |
| mechanismsOfAction: DrugDetailMechanismsOfAction | |
| linkedTargets: DrugDetailLinkedTargets | |
| linkedDiseases: DrugDetailLinkedDiseases | |
| adverseEvents: DrugDetailAdverseEvents | |
| } | |
| type DrugSummaries { | |
| mechanismsOfAction: DrugSummaryMechanismsOfAction | |
| linkedTargets: DrugSummaryLinkedTargets | |
| linkedDiseases: DrugSummaryLinkedDiseases | |
| adverseEvents: DrugSummaryAdverseEvents | |
| } | |
| type DrugSummaryAdverseEvents { | |
| eventsCount: Int! | |
| critval: Float! | |
| sources: [Source!]! | |
| } | |
| type DrugSummaryLinkedDiseases { | |
| linkedDiseaseCount: Int! | |
| sources: [Source!]! | |
| } | |
| type DrugSummaryLinkedTargets { | |
| linkedTargetCount: Int! | |
| sources: [Source!]! | |
| } | |
| type DrugSummaryMechanismsOfAction { | |
| uniqueActionTypes: [String!]! | |
| uniqueTargetTypes: [String!]! | |
| sources: [Source!]! | |
| } | |
| enum DrugType { | |
| SMALL_MOLECULE | |
| PROTEIN | |
| ENZYME | |
| ANTIBODY | |
| OLIGOSACCHARIDE | |
| OLIGONUCLEOTIDE | |
| UNKNOWN | |
| } | |
| type EvDrug { | |
| id: String! | |
| name: String! | |
| type: DrugType! | |
| activity: DrugActivity! | |
| } | |
| type Evidence { | |
| summaries: EvidenceSummaries! | |
| details: EvidenceDetails! | |
| } | |
| type EvidenceDetailAnimalModels { | |
| rows: [EvidenceRowAnimalModels!]! | |
| } | |
| type EvidenceDetailCancerGeneCensus { | |
| rows: [EvidenceRowCancerGeneCensus!]! | |
| } | |
| type EvidenceDetailCrispr { | |
| rows: [EvidenceRowCrispr!]! | |
| } | |
| type EvidenceDetailDifferentialExpression { | |
| rows: [EvidenceRowDifferentialExpression!]! | |
| } | |
| type EvidenceDetailDrugs { | |
| rows: [EvidenceRowDrugs!]! | |
| } | |
| type EvidenceDetailEva { | |
| rows: [EvidenceRowEva!]! | |
| } | |
| type EvidenceDetailEvaSomatic { | |
| rows: [EvidenceRowEvaSomatic!]! | |
| } | |
| type EvidenceDetailGene2Phenotype { | |
| rows: [EvidenceRowGene2Phenotype!]! | |
| } | |
| type EvidenceDetailGenomicsEngland { | |
| rows: [EvidenceRowGenomicsEngland!]! | |
| } | |
| type EvidenceDetailGwasCatalog { | |
| rows: [EvidenceRowGwasCatalog!]! | |
| } | |
| type EvidenceDetailIntogen { | |
| rows: [EvidenceRowIntogen!]! | |
| } | |
| type EvidenceDetailOtGenetics { | |
| rows: [EvidenceRowOtGenetics!]! | |
| } | |
| type EvidenceDetailPhewasCatalog { | |
| rows: [EvidenceRowPhewasCatalog!]! | |
| } | |
| type EvidenceDetailProgeny { | |
| rows: [EvidenceRowProgeny!]! | |
| } | |
| type EvidenceDetailReactome { | |
| rows: [EvidenceRowReactome!]! | |
| } | |
| type EvidenceDetails { | |
| animalModels: EvidenceDetailAnimalModels | |
| differentialExpression: EvidenceDetailDifferentialExpression | |
| drugs: EvidenceDetailDrugs | |
| gwasCatalog: EvidenceDetailGwasCatalog | |
| otGenetics: EvidenceDetailOtGenetics | |
| intogen: EvidenceDetailIntogen | |
| cancerGeneCensus: EvidenceDetailCancerGeneCensus | |
| phewasCatalog: EvidenceDetailPhewasCatalog | |
| reactome: EvidenceDetailReactome | |
| slapenrich: EvidenceDetailSlapenrich | |
| progeny: EvidenceDetailProgeny | |
| crispr: EvidenceDetailCrispr | |
| sysBio: EvidenceDetailSysBio | |
| eva: EvidenceDetailEva | |
| evaSomatic: EvidenceDetailEvaSomatic | |
| gene2Phenotype: EvidenceDetailGene2Phenotype | |
| genomicsEngland: EvidenceDetailGenomicsEngland | |
| uniProt: EvidenceDetailUniProt | |
| uniProtLiterature: EvidenceDetailUniProtLiterature | |
| uniProtSomatic: EvidenceDetailUniProtSomatic | |
| textMining: EvidenceDetailTextMining | |
| } | |
| type EvidenceDetailSlapenrich { | |
| rows: [EvidenceRowSlapenrich!]! | |
| } | |
| type EvidenceDetailSysBio { | |
| rows: [EvidenceRowSysBio!]! | |
| } | |
| type EvidenceDetailTextMining { | |
| rows: [EvidenceRowTextMining!]! | |
| textMiningCount: Int! | |
| } | |
| type EvidenceDetailUniProt { | |
| rows: [EvidenceRowUniProt!]! | |
| } | |
| type EvidenceDetailUniProtLiterature { | |
| rows: [EvidenceRowUniProtLiterature!]! | |
| } | |
| type EvidenceDetailUniProtSomatic { | |
| rows: [EvidenceRowUniProtSomatic!]! | |
| } | |
| type EvidenceMechanismOfAction { | |
| name: String! | |
| sourceUrl: String | |
| sourceName: String | |
| } | |
| type EvidenceRowAnimalModels { | |
| disease: Disease! | |
| humanPhenotypes: [Phenotype!]! | |
| modelPhenotypes: [Phenotype!]! | |
| modelId: String! | |
| allelicComposition: String! | |
| geneticBackground: String! | |
| source: Source! | |
| } | |
| type EvidenceRowCancerGeneCensus { | |
| disease: Disease! | |
| mutationType: String! | |
| inheritancePattern: InheritancePattern! | |
| samplesWithMutationTypeCount: Int! | |
| mutatedSamplesCount: Int! | |
| source: Source! | |
| pmIds: [String!]! | |
| } | |
| type EvidenceRowCrispr { | |
| disease: Disease! | |
| score: Float! | |
| method: String! | |
| pmId: String! | |
| } | |
| type EvidenceRowDifferentialExpression { | |
| disease: Disease! | |
| tissue: Tissue! | |
| activity: DifferentialExpressionActivity! | |
| comparison: String! | |
| evidenceSource: String! | |
| log2FoldChange: Float! | |
| percentileRank: Int! | |
| pval: Float! | |
| experiment: DifferentialExpressionExperiment! | |
| pmIds: [String!]! | |
| } | |
| type EvidenceRowDrugs { | |
| target: Target! | |
| disease: Disease! | |
| drug: EvDrug! | |
| clinicalTrial: ClinicalTrial! | |
| mechanismOfAction: EvidenceMechanismOfAction! | |
| } | |
| type EvidenceRowEva { | |
| disease: Disease! | |
| rsId: String! | |
| clinVarId: String! | |
| vepConsequence: VEPConsequence! | |
| clinicalSignificance: String! | |
| pmId: String | |
| } | |
| type EvidenceRowEvaSomatic { | |
| disease: Disease! | |
| rsId: String! | |
| clinVarId: String! | |
| vepConsequence: VEPConsequence! | |
| clinicalSignificance: String! | |
| pmId: String | |
| } | |
| type EvidenceRowGene2Phenotype { | |
| disease: Disease! | |
| panelsUrl: String! | |
| pmId: String! | |
| } | |
| type EvidenceRowGenomicsEngland { | |
| disease: Disease! | |
| panel: GenomicsEnglandPanel! | |
| source: Source | |
| } | |
| type EvidenceRowGwasCatalog { | |
| disease: Disease! | |
| rsId: String! | |
| pval: Float! | |
| oddsRatio: Float | |
| confidenceInterval: String | |
| vepConsequence: VEPConsequence | |
| source: Source! | |
| } | |
| type EvidenceRowIntogen { | |
| disease: Disease! | |
| activity: IntogenActivity! | |
| inheritancePattern: InheritancePattern! | |
| source: Source! | |
| pmId: String! | |
| } | |
| type EvidenceRowOtGenetics { | |
| disease: Disease! | |
| reportedTrait: Trait | |
| publications: [SimpleOtGeneticsPublication] | |
| variant: Variant! | |
| pval: PVal! | |
| genePrioritisationScore: Float! | |
| source: Source! | |
| } | |
| type EvidenceRowPhewasCatalog { | |
| disease: Disease! | |
| rsId: String! | |
| pval: Float! | |
| oddsRatio: Float | |
| confidenceInterval: String | |
| vepConsequence: VEPConsequence | |
| source: Source! | |
| } | |
| type EvidenceRowProgeny { | |
| disease: Disease! | |
| pathway: ReactomePathway! | |
| source: Source! | |
| } | |
| type EvidenceRowReactome { | |
| activity: ReactomeActivity | |
| disease: Disease! | |
| pathway: ReactomePathway! | |
| mutations: [String!]! | |
| source: Source! | |
| } | |
| type EvidenceRowSlapenrich { | |
| disease: Disease! | |
| pathway: ReactomePathway! | |
| source: Source! | |
| } | |
| type EvidenceRowSysBio { | |
| disease: Disease! | |
| geneSet: String! | |
| method: String! | |
| pmId: String! | |
| } | |
| type EvidenceRowTextMining { | |
| access: String! | |
| disease: Disease! | |
| journal: Journal! | |
| publication: Publication! | |
| relevance: Float! | |
| } | |
| type EvidenceRowUniProt { | |
| disease: Disease! | |
| rsId: String! | |
| vepConsequence: VEPConsequence! | |
| source: Source! | |
| pmIds: [String!]! | |
| } | |
| type EvidenceRowUniProtLiterature { | |
| disease: Disease! | |
| source: Source! | |
| pmIds: [String!]! | |
| } | |
| type EvidenceRowUniProtSomatic { | |
| disease: Disease! | |
| vepConsequence: VEPConsequence! | |
| source: Source! | |
| pmIds: [String!]! | |
| } | |
| type EvidenceSummaries { | |
| animalModels: EvidenceSummaryAnimalModels | |
| differentialExpression: EvidenceSummaryDifferentialExpression | |
| drugs: EvidenceSummaryDrugs | |
| gwasCatalog: EvidenceSummaryGwasCatalog | |
| otGenetics: EvidenceSummaryOtGenetics | |
| intogen: EvidenceSummaryIntogen | |
| cancerGeneCensus: EvidenceSummaryCancerGeneCensus | |
| phewasCatalog: EvidenceSummaryPhewasCatalog | |
| reactome: EvidenceSummaryReactome | |
| slapenrich: EvidenceSummarySlapenrich | |
| progeny: EvidenceSummaryProgeny | |
| crispr: EvidenceSummaryCrispr | |
| sysBio: EvidenceSummarySysBio | |
| eva: EvidenceSummaryEva | |
| evaSomatic: EvidenceSummaryEvaSomatic | |
| gene2Phenotype: EvidenceSummaryGene2Phenotype | |
| genomicsEngland: EvidenceSummaryGenomicsEngland | |
| uniProt: EvidenceSummaryUniProt | |
| uniProtLiterature: EvidenceSummaryUniProtLiterature | |
| uniProtSomatic: EvidenceSummaryUniProtSomatic | |
| textMining: EvidenceSummaryTextMining | |
| } | |
| type EvidenceSummaryAnimalModels { | |
| mouseModelCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryCancerGeneCensus { | |
| hasMutations: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryCrispr { | |
| hasCrispr: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryDifferentialExpression { | |
| experimentCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryDrugs { | |
| drugCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryEva { | |
| variantCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryEvaSomatic { | |
| variantCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryGene2Phenotype { | |
| hasPanel: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryGenomicsEngland { | |
| hasPanel: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryGwasCatalog { | |
| variantCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryIntogen { | |
| hasMutations: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryOtGenetics { | |
| variantCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryPhewasCatalog { | |
| variantCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryProgeny { | |
| pathwayCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryReactome { | |
| pathwayCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummarySlapenrich { | |
| pathwayCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummarySysBio { | |
| hasSysBio: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryTextMining { | |
| textMiningCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryUniProt { | |
| variantCount: Int! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryUniProtLiterature { | |
| hasVariants: Boolean! | |
| sources: [Source!]! | |
| } | |
| type EvidenceSummaryUniProtSomatic { | |
| hasVariants: Boolean! | |
| sources: [Source!]! | |
| } | |
| type ExpandedRowRelatedDisease { | |
| target: Target! | |
| associationScoreA: Float! | |
| associationScoreB: Float! | |
| } | |
| type ExpandedRowRelatedTarget { | |
| disease: Disease! | |
| associationScoreA: Float! | |
| associationScoreB: Float! | |
| } | |
| enum GeneOntologyCategory { | |
| CELLULAR_COMPONENT | |
| BIOLOGICAL_PROCESS | |
| MOLECULAR_FUNCTION | |
| } | |
| type GenomicsEnglandPanel { | |
| id: String! | |
| url: String! | |
| } | |
| type HomologyRow { | |
| dNdS: Float | |
| species: String! | |
| speciesId: String! | |
| homologyType: String! | |
| queryPercentageIdentity: Float! | |
| targetPercentageIdentity: Float! | |
| targetGeneId: String! | |
| targetGeneSymbol: String | |
| } | |
| type Indication { | |
| id: String! | |
| name: String! | |
| therapeuticAreas: [Disease!]! | |
| maxPhase: Int | |
| } | |
| enum InheritancePattern { | |
| X_LINKED_RECESSIVE | |
| DOMINANT_OR_RECESSIVE | |
| DOMINANT | |
| RECESSIVE | |
| UNKNOWN | |
| } | |
| enum IntogenActivity { | |
| GAIN_OF_FUNCTION | |
| LOSS_OF_FUNCTION | |
| UNKNOWN | |
| } | |
| type Journal { | |
| title: String! | |
| volume: String | |
| issue: String | |
| page: String | |
| year: Int | |
| } | |
| type LowLevelReactomePathway { | |
| id: String! | |
| name: String! | |
| parents: [ReactomePathway!]! | |
| } | |
| type Match { | |
| start: Int! | |
| end: Int! | |
| } | |
| type MechanismOfActionRow { | |
| mechanismOfAction: String! | |
| targetName: String! | |
| targets: [Target!]! | |
| references: [Source!]! | |
| } | |
| type MousePhenotypeCategory { | |
| id: String! | |
| name: String! | |
| isAssociated: Boolean! | |
| } | |
| type MousePhenotypeRow { | |
| mouseGeneId: String! | |
| mouseGeneSymbol: String! | |
| categoryId: String! | |
| categoryLabel: String! | |
| phenotypeId: String! | |
| phenotypeLabel: String! | |
| subjectAllelicComposition: [String!]! | |
| subjectBackground: String! | |
| pmIds: [String!]! | |
| } | |
| type OrthologuesBySpecies { | |
| species: String! | |
| speciesId: String! | |
| orthologuesCount: Int! | |
| } | |
| type PageInfo { | |
| nextCursor: String | |
| hasNextPage: Boolean! | |
| } | |
| type Phenotype { | |
| id: String! | |
| name: String! | |
| url: String! | |
| } | |
| type Protein { | |
| level: Int! | |
| } | |
| type ProteinInteractionsGraphEdge { | |
| source: String! | |
| target: String! | |
| isDirected: Boolean! | |
| isStimulation: Boolean! | |
| isInhibition: Boolean! | |
| pmIds: [String!]! | |
| sources: [String!]! | |
| pathwaysSources: [String!]! | |
| enzymeSubstrateSources: [String!]! | |
| ppiSources: [String!]! | |
| } | |
| type ProteinInteractionsGraphNode { | |
| uniprotId: String! | |
| ensgId: String! | |
| symbol: String! | |
| } | |
| type Publication { | |
| id: String! | |
| title: String! | |
| date: String! | |
| authors: [Author!]! | |
| url: String | |
| abstract: String | |
| matches: [[SectionMatch]] | |
| } | |
| type PVal { | |
| mantissa: Float | |
| exponent: Int | |
| value: Float! | |
| } | |
| type Query { | |
| target(ensgId: String!): Target! | |
| disease(efoId: String!): Disease! | |
| drug(chemblId: String!): Drug! | |
| efo: DiseaseOntology! | |
| evidence(ensgId: String!, efoId: String!, from: Int, size: Int, sortBy: String, order: String): Evidence! | |
| } | |
| enum ReactomeActivity { | |
| DECREASED_TRANSCRIPT_LEVEL | |
| GAIN_OF_FUNCTION | |
| LOSS_OF_FUNCTION | |
| PARTIAL_LOSS_OF_FUNCTION | |
| UP_OR_DOWN | |
| } | |
| type ReactomePathway { | |
| id: String! | |
| name: String! | |
| } | |
| type Rna { | |
| value: Float! | |
| level: Int! | |
| } | |
| type RowCancerBiomarkers { | |
| biomarker: String! | |
| diseases: [Disease!]! | |
| drugName: String! | |
| associationType: AssociationType! | |
| evidenceLevel: String! | |
| sources: [Source!]! | |
| } | |
| type RowChemicalProbes { | |
| chemicalProbe: String! | |
| note: String | |
| sources: [Source!]! | |
| } | |
| type RowExpression { | |
| label: String! | |
| organs: [String!]! | |
| anatomicalSystems: [String!]! | |
| rna: Rna! | |
| protein: Protein! | |
| } | |
| type RowGeneOntology { | |
| id: String! | |
| term: String! | |
| category: GeneOntologyCategory! | |
| } | |
| type RowRelatedDisease { | |
| A: Disease! | |
| B: Disease! | |
| targetCountA: Int! | |
| targetCountB: Int! | |
| targetCountAAndB: Int! | |
| targetCountAOrB: Int! | |
| score: Float! | |
| } | |
| type RowRelatedTarget { | |
| A: Target! | |
| B: Target! | |
| diseaseCountA: Int! | |
| diseaseCountB: Int! | |
| diseaseCountAAndB: Int! | |
| diseaseCountAOrB: Int! | |
| score: Float! | |
| } | |
| type ScoreForDataSource { | |
| dataSourceId: DataSource! | |
| score: Float! | |
| } | |
| type ScoreForDataType { | |
| dataTypeId: DataType! | |
| score: Float! | |
| } | |
| type SectionMatch { | |
| text: String! | |
| section: String! | |
| target: Match | |
| disease: Match | |
| } | |
| type SimpleOtGeneticsPublication { | |
| authors: [String] | |
| url: String | |
| year: String | |
| pmId: String! | |
| } | |
| type SinglyNestedCategoryFacetItem { | |
| itemId: String! | |
| name: String! | |
| count: Int! | |
| children: [CategoryFacetItem!]! | |
| } | |
| type Source { | |
| url: String! | |
| name: String | |
| } | |
| type Target { | |
| id: String! | |
| uniprotId: String! | |
| symbol: String! | |
| name: String! | |
| description: String | |
| synonyms: [String!]! | |
| summaries: TargetSummaries! | |
| details: TargetDetails! | |
| diseasesConnection(facets: TargetDiseasesConnectionFacetsInput, sortBy: TargetDiseasesConnectionSortByInput, first: Int, after: String, search: String): TargetDiseasesConnection! | |
| } | |
| type TargetDetailCancerBiomarkers { | |
| rows: [RowCancerBiomarkers!]! | |
| } | |
| type TargetDetailCancerHallmarks { | |
| publicationsByHallmark: [CancerHallmarkPublicationsByHallmark!]! | |
| roleInCancer: [CancerHallmarkRoleInCancer!]! | |
| rows: [CancerHallmarkPublicationFullDetails!]! | |
| } | |
| type TargetDetailChemicalProbes { | |
| rows: [RowChemicalProbes!]! | |
| probeMinerUrl: String | |
| } | |
| type TargetDetailDrugs { | |
| rows: [EvidenceRowDrugs!]! | |
| } | |
| type TargetDetailExpression { | |
| rows: [RowExpression!]! | |
| } | |
| type TargetDetailGeneOntology { | |
| rows: [RowGeneOntology!]! | |
| } | |
| type TargetDetailHomology { | |
| rows: [HomologyRow!]! | |
| } | |
| type TargetDetailMousePhenotypes { | |
| categories: [MousePhenotypeCategory!]! | |
| rows: [MousePhenotypeRow!]! | |
| } | |
| type TargetDetailPathways { | |
| topLevelPathways: [TopLevelReactomePathway!]! | |
| lowLevelPathways: [LowLevelReactomePathway!]! | |
| } | |
| type TargetDetailProtein { | |
| uniprotId: String | |
| keywords: [UniprotKeyword!] | |
| subCellularLocations: [UniprotSubCellularLocation!] | |
| subUnit: [String!] | |
| } | |
| type TargetDetailProteinInteractions { | |
| nodes: [ProteinInteractionsGraphNode!]! | |
| edges: [ProteinInteractionsGraphEdge!]! | |
| } | |
| type TargetDetailRelatedTargets { | |
| rows: [RowRelatedTarget!]! | |
| expanded(otherEnsgId: String!): [ExpandedRowRelatedTarget!]! | |
| } | |
| type TargetDetails { | |
| cancerBiomarkers: TargetDetailCancerBiomarkers | |
| cancerHallmarks: TargetDetailCancerHallmarks | |
| chemicalProbes: TargetDetailChemicalProbes | |
| drugs: TargetDetailDrugs | |
| expression: TargetDetailExpression | |
| geneOntology: TargetDetailGeneOntology | |
| homology: TargetDetailHomology | |
| mousePhenotypes: TargetDetailMousePhenotypes | |
| pathways: TargetDetailPathways | |
| protein: TargetDetailProtein | |
| proteinInteractions: TargetDetailProteinInteractions | |
| relatedTargets: TargetDetailRelatedTargets | |
| tractability: TargetDetailTractability | |
| } | |
| type TargetDetailTractability { | |
| smallMolecule: [TractabilityAssessmentBucket!]! | |
| antibody: [TractabilityAssessmentBucket!]! | |
| } | |
| type TargetDiseasesConnection { | |
| totalCount: Int! | |
| facets: TargetDiseasesConnectionFacets! | |
| edges: [TargetDiseasesConnectionEdge!]! | |
| pageInfo: PageInfo! | |
| } | |
| type TargetDiseasesConnectionEdge { | |
| id: String! | |
| node: Disease! | |
| score: Float! | |
| scoresByDataType: [ScoreForDataType!]! | |
| scoresByDataSource: [ScoreForDataSource!]! | |
| } | |
| type TargetDiseasesConnectionFacetDataTypeAndSource { | |
| items: [DataTypeFacetItem!]! | |
| } | |
| input TargetDiseasesConnectionFacetInputDataTypeAndSource { | |
| dataTypeIds: [DataType!] | |
| dataSourceIds: [DataSource!] | |
| } | |
| input TargetDiseasesConnectionFacetInputTherapeuticArea { | |
| efoIds: [String!]! | |
| } | |
| type TargetDiseasesConnectionFacets { | |
| dataTypeAndSource: TargetDiseasesConnectionFacetDataTypeAndSource | |
| therapeuticArea: TargetDiseasesConnectionFacetTherapeuticArea | |
| } | |
| input TargetDiseasesConnectionFacetsInput { | |
| dataTypeAndSource: TargetDiseasesConnectionFacetInputDataTypeAndSource | |
| therapeuticArea: TargetDiseasesConnectionFacetInputTherapeuticArea | |
| } | |
| type TargetDiseasesConnectionFacetTherapeuticArea { | |
| items: [CategoryFacetItem!]! | |
| } | |
| enum TargetDiseasesConnectionSortByField { | |
| GENETIC_ASSOCIATION | |
| SOMATIC_MUTATION | |
| KNOWN_DRUGS | |
| PATHWAYS | |
| DIFFERENTIAL_EXPRESSION | |
| ANIMAL_MODELS | |
| TEXT_MINING | |
| SCORE_OVERALL | |
| DISEASE_NAME | |
| } | |
| input TargetDiseasesConnectionSortByInput { | |
| field: TargetDiseasesConnectionSortByField! | |
| ascending: Boolean! | |
| } | |
| type TargetSummaries { | |
| cancerBiomarkers: TargetSummaryCancerBiomarkers | |
| cancerHallmarks: TargetSummaryCancerHallmarks | |
| chemicalProbes: TargetSummaryChemicalProbes | |
| drugs: TargetSummaryDrugs | |
| expression: TargetSummaryExpression | |
| geneOntology: TargetSummaryGeneOntology | |
| homology: TargetSummaryHomology | |
| mousePhenotypes: TargetSummaryMousePhenotypes | |
| pathways: TargetSummaryPathways | |
| protein: TargetSummaryProtein | |
| proteinInteractions: TargetSummaryProteinInteractions | |
| relatedTargets: TargetSummaryRelatedTargets | |
| tractability: TargetSummaryTractability | |
| variation: TargetSummaryVariation | |
| } | |
| type TargetSummaryCancerBiomarkers { | |
| hasCancerBiomarkers: Boolean! | |
| cancerBiomarkerCount: Int! | |
| diseaseCount: Int! | |
| drugCount: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryCancerHallmarks { | |
| promotionAndSuppressionByHallmark: [CancerHallmarkPromotionAndSuppression!]! | |
| roleInCancer: [CancerHallmarkRoleInCancer!]! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryChemicalProbes { | |
| hasStructuralGenomicsConsortium: Boolean! | |
| hasChemicalProbesPortal: Boolean! | |
| hasOpenScienceProbes: Boolean! | |
| hasProbeMiner: Boolean! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryDrugs { | |
| drugCount: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryExpression { | |
| rnaBaselineExpression: Boolean! | |
| proteinBaselineExpression: Boolean! | |
| expressionAtlasExperiment: Boolean! | |
| gtexData: Boolean! | |
| } | |
| type TargetSummaryGeneOntology { | |
| molecularFunctionTermsCount: Int! | |
| biologicalProcessTermsCount: Int! | |
| cellularComponentTermsCount: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryHomology { | |
| paraloguesCount: Int! | |
| orthologuesBySpecies: [OrthologuesBySpecies!]! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryMousePhenotypes { | |
| phenotypeCount: Int! | |
| categoryCount: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryPathways { | |
| count: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryProtein { | |
| hasSubCellularLocation: Boolean! | |
| hasSubUnitData: Boolean! | |
| hasUniprotKeywords: Boolean! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryProteinInteractions { | |
| ppi: Int! | |
| pathways: Int! | |
| enzymeSubstrate: Int! | |
| interactorsCount: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryRelatedTargets { | |
| relatedTargetsCount: Int! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryTractability { | |
| hasSmallMoleculeTractabilityAssessment: Boolean! | |
| hasAntibodyTractabilityAssessment: Boolean! | |
| sources: [Source!]! | |
| } | |
| type TargetSummaryVariation { | |
| common: VariationCommon! | |
| rare: VariationRare! | |
| sources: [Source!]! | |
| } | |
| type Tissue { | |
| id: String! | |
| name: String! | |
| } | |
| type TissueSpecificityFacetItem { | |
| itemId: String! | |
| name: String! | |
| organs: [String!]! | |
| anatomicalSystems: [String!]! | |
| } | |
| type TopLevelReactomePathway { | |
| id: String! | |
| name: String! | |
| isAssociated: Boolean! | |
| } | |
| type TractabilityAssessmentBucket { | |
| chemblBucket: Int! | |
| description: String! | |
| value: Boolean! | |
| } | |
| type Trait { | |
| name: String! | |
| url: String! | |
| } | |
| type UniprotKeyword { | |
| id: String! | |
| name: String! | |
| category: String! | |
| } | |
| type UniprotSubCellularLocation { | |
| id: String! | |
| name: String! | |
| description: String! | |
| } | |
| """The `Upload` scalar type represents a file upload.""" | |
| scalar Upload | |
| type Variant { | |
| id: String! | |
| url: String! | |
| } | |
| type VariationCommon { | |
| variantsCount: Int! | |
| diseasesCount: Int! | |
| } | |
| type VariationRare { | |
| mutationsCount: Int! | |
| diseasesCount: Int! | |
| } | |
| enum VEPConsequence { | |
| TRANSCRIPT_ABLATION | |
| SPLICE_ACCEPTOR_VARIANT | |
| SPLICE_DONOR_VARIANT | |
| STOP_GAINED | |
| FRAMESHIFT_VARIANT | |
| STOP_LOST | |
| START_LOST | |
| TRANSCRIPT_AMPLIFICATION | |
| INFRAME_INSERTION | |
| INFRAME_DELETION | |
| MISSENSE_VARIANT | |
| PROTEIN_ALTERING_VARIANT | |
| SPLICE_REGION_VARIANT | |
| INCOMPLETE_TERMINAL_CODON_VARIANT | |
| START_RETAINED_VARIANT | |
| STOP_RETAINED_VARIANT | |
| SYNONYMOUS_VARIANT | |
| CODING_SEQUENCE_VARIANT | |
| MATURE_MIRNA_VARIANT | |
| FIVE_PRIME_UTR_VARIANT | |
| THREE_PRIME_UTR_VARIANT | |
| NON_CODING_TRANSCRIPT_EXON_VARIANT | |
| INTRON_VARIANT | |
| NMD_TRANSCRIPT_VARIANT | |
| NON_CODING_TRANSCRIPT_VARIANT | |
| UPSTREAM_GENE_VARIANT | |
| DOWNSTREAM_GENE_VARIANT | |
| TFBS_ABLATION | |
| TFBS_AMPLIFICATION | |
| TF_BINDING_SITE_VARIANT | |
| REGULATORY_REGION_ABLATION | |
| REGULATORY_REGION_AMPLIFICATION | |
| FEATURE_ELONGATION | |
| REGULATORY_REGION_VARIANT | |
| FEATURE_TRUNCATION | |
| INTERGENIC_VARIANT | |
| NEAREST_GENE_COUNTING_FROM_FIVE_PRIME_END | |
| SEQUENCE_VARIANT | |
| } | |
| type WithdrawnNotice { | |
| classes: [String!] | |
| countries: [String!]! | |
| reasons: [String!] | |
| year: String! | |
| } | |
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